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The Macleay Collections house some 1370 reptile specimens and some 1000 amphibian specimens.

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The Herpetology Section possesses reptiles and amphibians from Denmark and the rest of Europe. From the earlier settlements on the Coast of Guinea, the Museum possesses a small, but very fine collection of snakes, among others the spitting cobra, Naja nigricollis, anuran amphibians, East African tree frogs, and other representative collections of reptiles and amphibians.

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The Herpetological collections date from the early 1740s, and are rich in historical items, including Linnaean types. The Collections include representatives of most of the currently recognised families. It is estimated that the Herpetology collections have a total of about 50,000 specimens in about 10,000 lots. A small portion of this herpetological material (some 2,000) lots has been computer catalogued and can be accessed through their Herpetology Collection Search Database.

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The Swiss Amphibian and Reptile Conservation Programme (KARCH) represents the official task force in Switzerland to promote, implement and coordinate efforts to conserve the Swiss amphibian and reptile fauna, which is protected by law in Switzerland since 1967.

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The Herpetology Department has some 40,000 reptile and amphibian specimens. The collection is unique for its richness in early "New World" species including many specimens from Panama and Costa Rica.

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